CovidV2, Main, Exploration, bibRecord, 001511

Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Identifieur interne : 001511 ( Main/Exploration ); précédent : 001510; suivant : 001512

Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Auteurs : Yoon-Suk Lee [Corée du Sud] ; Sun Min Park ; Byeang Hyean Kim

Source :

Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2009.

RBID : pubmed:19147352

Descripteurs français

KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Désoxyuridine (), Désoxyuridine (analogues et dérivés), Désoxyuridine (pharmacologie), Désoxyuridine (synthèse chimique), Isoxazoles (), Isoxazoles (pharmacologie), Isoxazoles (synthèse chimique), Simplexvirus (), Structure moléculaire, Techniques de chimie combinatoire, Tests de sensibilité microbienne, Virus à ARN ().
MESH :
- analogues et dérivés : Désoxyuridine.
- pharmacologie : Antiviraux, Désoxyuridine, Isoxazoles.
- synthèse chimique : Antiviraux, Désoxyuridine, Isoxazoles.
- Antiviraux, Désoxyuridine, Isoxazoles, Simplexvirus, Structure moléculaire, Techniques de chimie combinatoire, Tests de sensibilité microbienne, Virus à ARN.

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Combinatorial Chemistry Techniques, Deoxyuridine (analogs & derivatives), Deoxyuridine (chemical synthesis), Deoxyuridine (chemistry), Deoxyuridine (pharmacology), Isoxazoles (chemical synthesis), Isoxazoles (chemistry), Isoxazoles (pharmacology), Microbial Sensitivity Tests, Molecular Structure, RNA Viruses (drug effects), Simplexvirus (drug effects).
MESH :
- chemical , analogs & derivatives : Deoxyuridine.
- chemical , chemical synthesis : Antiviral Agents, Deoxyuridine, Isoxazoles.
- chemical , chemistry : Antiviral Agents, Deoxyuridine, Isoxazoles.
- chemical , pharmacology : Antiviral Agents, Deoxyuridine, Isoxazoles.
- drug effects : RNA Viruses, Simplexvirus.
- Combinatorial Chemistry Techniques, Microbial Sensitivity Tests, Molecular Structure.

Abstract

This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2'-deoxyuridines from 5-iodo-2'-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2'-deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these isoxazoles were, however, inactive against corona virus, influenza virus, and HIV.

DOI: 10.1016/j.bmcl.2008.12.103
PubMed: 19147352

Affiliations:

Corée du Sud

Le document en format XML

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Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Covid (26 mars)
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